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Image Search Results
Journal: Cell Death Discovery
Article Title: CLC3 regulates V-ATPase to enhance lysosomal degradation and cisplatin resistance in cervical cancer cells
doi: 10.1038/s41420-025-02876-0
Figure Lengend Snippet: A Relative CLC3 mRNA expression levels in various CVC cell lines (SiHa, MS751, HeLa, ME180, Hela229, CaSKi) compared to normal cervical epithelial cells (NCCs). * P < 0.05, ** P < 0.001. vs. NCCs. B Western blot analysis showing CLC3 protein expression in NCCs and different CVC cell lines (SiHa, MS751, HeLa, ME180, Hela229, CaSKi), with GAPDH as a loading control. * P < 0.05, ** P < 0.001. vs. NCCs. C CLC3 mRNA expression in CVC cell lines (SiHa, MS751, HeLa, ME180, Hela229, and CaSKi) following CLC3 overexpression (CLC3 High ) or knockdown (CLC3 Low ) compared to control. * P < 0.05, ** P < 0.001. vs. Control. D Western blot analysis of CLC3 protein levels in CLC3 High , CLC3 Low , and control cells across the same cell lines, with quantification shown in the accompanying graphs. * P < 0.05, ** P < 0.001. vs. Control. E IC50 values for cisplatin, paclitaxel, and 5-FU in CLC3 High , CLC3 Low , and control groups in SiHa and CaSKi cells, showing CLC3 modulation’s effect on chemoresistance. * P < 0.05 vs. Control.
Article Snippet: CVC cell lines (SiHa, MS751, HeLa, ME180, Hela229, CaSKi) and
Techniques: Expressing, Western Blot, Control, Over Expression, Knockdown